Papers Published

Title: Development of a Process to Manufacture PEGylated Orally Bioavailable Insulin
Authors: Partha Hazra, Laxmi Adhikary, Nitesh Dave, Anand Khedkar, H.S. Manjunath, Ramya Anantharaman, and Harish Iyer
Journal: Biotechnol. Prog., 2010, Vol. 26, No. 6, 1695-1704

Title: Nimotuzumab with chemoradiation confers survival advantage in treatment naïve head and neck tumors overexpressing EGFR.
Authors: Basavaraj C, Sierra P, Shivu J, Melarkode R, Montero E, Nair P.  
Journal: Cancer Biol Ther. 10(7). 2010 Oct 25

Title: CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction. 
Authors: Nair P, Melarkode R, Rajkumar D, Montero E. 
Journal: Clin Exp Immunol. 2010 Aug 19.

Title: A dose range finding study of novel oral insulin (IN-105) under fed conditions in Type 2 Diabetes Mellitus subjects; Manuscript accepted for publication in Diabetes
Authors: Anand Khedkar, Harish Iyer, Verma M
Journal: Obesity and Metab; DOM 09-0499-OP.R1.

Title: Oral Insulin – Review of current status
Authors: Harish Iyer, Anand Khedkar, Verma M
Journal: Diabetes, Obesity and Metabolism; 2010; 12:179-185.

Title: Probing deamidation in therapeutic immunoglobulin gamma (lgG1) by bottoms up mass spectrometry with electron transfer dissociation
Authors: Raju Mukherjee, Laxmi Adhikary, Anand Khedkar, Harish Iyer
Journal: Rapid commun mass spectrum; 2010; 24; 879-884; DOI 10.1002/rcm.4464

Title: Nimotuzumab, a promising therapeutic monoclonal for treatment of tumors of epithelial origin
Authors: Melarkode S. Ramakrishnan, Anand Eswaraiah, Tania Crombet, Patricia Piedra, Giselle Saurez, Harish Iyer and A.S. Arvind
Journal: mAbs 1:1, 41-48, January/February 2009.

Title: Yeasts and filamentous fungi as hosts for recombinant protein production. In Biotechnology Concepts and Applications
Authors: Nagaraj G., Dave K., Sastry K.N. and Punekar N.S.
Journal: Eds Vittal R.R. and Bhat R., Narosa Publishing house, New Delhi, pp 183-221, 2009.

Title: Identification of the dipeptidyl aminopeptidase responsible for N-terminal clipping of recombinant Exendin -4 precursor expressed in Pichia pastoris.
Authors: Prabha L, Govindappa N, Adhikary L, Melarkode R, Sastry K
Journal: Protein Expr Purif. 64: 155-161, 2009.

Title: A tandem mass spectrometric approach to the identification of O-glycosylated glargine glycoforms in active pharmaceutical ingredient expressed in Pichia pastoris.
Authors: Vivekanandan Kannan, Pradeep Narayanaswamy, Deepak Gadamsetty, Partha Hazra, Anand Khedkar and Harish Iyer
Journal: Rapid Commun. Mass Spectrom. 23: 1035–1042, 2009.

Title: Relevance of biomarkers in a phase IIB head and neck trial using nimotuzumab
Authors: Pradip Nair, Chetana Basavaraj, Patricia Sierra, Jatteppanavar Shivu, Ramakrishnan Melarkode
Journal: ASCO Molecular Markers Meeting, Abstract No: 57, Florida, Miami 2008.

Title: Procedure for chromatography involving sample solvent with higher elution strength than the mobile phase
Authors: N. S. Patil, R. B. Mendhe, A. Sankar and H. Iyer
Journal: J. Chromatogr. A 1177(2), 234 - 242, 2008.

Title: Process and purification for manufacture of a modified insulin intended for oral delivery
Authors: Nitesh Dave, Partha Hazra, Anand Khedkar, H.S. Manjunath, Harish Iyer, Shrikumar Suryanarayanan
Journal: J. Chromatogr. A, 1177, 282–286, 2008.

Title: Vittatispora, a new melanosporaceous genus from Indian soil
Authors: Kedarnath N. Sastry, Preeti Chaudhary, Jinx Campbell, David L. Hawksworth
Journal: Mycologia, 98(3), pp. 460-467, 2006.

Presentations

Conference Name: 3rd conference on advanced technologies and treatments for diabetes
Date: 10th – 13th February, 2010
Venue: Basel
Title: “IN-105: A Potential Therapy on the rise for PPG control”
Authors:  Harish Iyer

Conference Name: 9th Diabetes Technology Conference
Date: 5th – 7th November, 2009
Venue: San Francisco
Title: “IN-105 – A Novel Insulin Analogue”
Authors:  Anand Khedkar

Conference Name: ADA 2009
Date: June 2009
Venue: New Orleans
Title: A dose escalation study of IN-105 (Insulin Analogue) tablets in type 2 diabetes Mellitus subjects
Authors: Harish Iyer, Anand Khedkar, Manish Verma, Sharmitha Krishnamurthy, Arun Anand

Conference Name: 21st meeting of European Society for Animal Cell technology
Date: June 2009
Venue: Dublin, Ireland
Title: Are clones really 'unstable'?
Authors: Kriti Shukla, Saravanan Desan, Ankur Bhatnagar, Anuj Goel

Conference Name: 21st meeting of European Society for Animal Cell technology
Date: June 2009
Venue: Dublin, Ireland
Title: Manipulation of a perfusion process by medium optimization
Authors: Saravanan Desan, Omkar Nandi, Ankur Bhatnagar, Anuj Goel

Conference Name: Asia Antibody Congress 2008
Date: September 2008
Venue: Singapore
Title: Monoclonal Drug Development – An Indian Perspective
Author: Ramakrishnan Melarkode

Conference Name: European Association for Study of Diabetes conference, 2008
Date: September 2008
Venue: Rome
Title: An open label two period placebo controlled study to evaluate the effect of food on pharmacokinetic and pharmacodynamic of IN-105 (10 mg) in type II diabetes mellitus patients
Authors: Harish Iyer, A. Khedkar, S. Suryanarayan, A. Anand, A. Vedala, S. Krishnamurthy, A.S. Arvind, A. Eswaraiah, S. Savale, S. R. Arvind, S. S. Srikanta

Conference Name:BioMedical Asia conference 2008
Date: April 2008
Venue: Singapore
Title: Process optimization and Scale-up for manufacture of a monoclonal antibody.
Author: Anuj Goel

Conference Name: Biotechnology and Ethics
Date: January 2008
Venue: Auxillium College, Vellore
Title: Industrial Biotechnology Perspective and Challenges
Authors: Anuj Goel

Conference Name: Engineering Conferences International (ECI)
Date: June 22 – June 26, 2008
Venue: Whistler, British Columbia, Vancouver, Canada
Title: Natural Products Discovery & Production II: Celebrating the success of traditional & Novel culture sources
Author: Sanjay Tiwari

Conference Name:  Prep-2008
Date: June 2008
Venue: San Jose, CA, USA
Title: “Development and Purification of Oral human Brain Natriuretic Peptide”
Authors: N Dave*, Suma S, K Sastry, P Hazra, L Adhikary, G Selvi, A Khedkar, H Iyer

Conference Name: National Seminar on Biotechnology & Bioengineering (NSBB) – 2007
Date: December 19, 2007
Venue: Delhi College of Engineering (DCE), Delhi
Title: Corporate Meet on Knowledge Park & National Seminar on Latest research & Industrial trends in Biotechnology & Bioengineering
Author: Sanjay Tiwari

Conference Name: "Recent Advances in Fermentation Technology - VII"
Date: 4th - 7th November, 2007
Venue: St. Pete's, Florida, USA
Title: Economics of a Repeated Fed Batch Fermentation Process for a Low-Value Entities.
Authors: Deepa D, Naveen G, Deepthy S, Saurabh Garg, Sanjay Tiwari

Conference Name: "20th Meeting of the European Society for Animal Cell Technology (ESACT)"
Date: 17th - 20th June, 2007
Venue: Dresden, Germany
Title: “Monoclonal Antibody production in NSO media optimization for a second generation process”
Authors: Ankur Bhatnagar, Saravanan Desan, Anuj Goel, Shrikumar Suryanarayan, Jyothi Iyer, Laxmi Adhikari, Hema Balasubramanian, Pradip Nair, Kriti Shukla, Ashita Magal, charu kumar, Soloman Alva.
Title: “Monoclonal Antibody production in a perfusion bioreactor. Investigation of changes for scale-up in an existing manufacturing process”
Authors: Anuj Goel, Ankur Bhatnagar, Saravanan Desan, Shrikumar Suryanarayan, Jyothi Iyer, Laxmi Adhikari, Hema Balasubramanian, Pradip Nair.

Conference Name:  Prep-2007
Date:  3rd – 6th June 2007
Venue:  Baltimore, Maryland, USA
Title: “Development of a novel preparative RP-HPLC process for removal of Glycosylated Insulin”
Authors: Krithika. T, Venkatesan. K, N. Dave*, L. Adhikary, H. Iyer

Conference Name: 5th HIC
Date: 20th – 24th March, 2007
Venue: Interlaken, Switzerland
Title: “Procedure for chromatography involving sample solvent with higher elution strength than the mobile phase”
Authors:  N. Patil, R. Mendhe, A. Sankar, H. Iyer.

Conference Name: 10th International symposium on the "Genetics of Industrial Microorganisms"
Date: 24th - 28th June, 2006
Venue: Prague, Czech Republic
Title: “Expression of glycine extended Exendin-4 in Pichia pastoris”
Authors:  Prabha L, Govindappa N, Melarkode R, Sastry K, Suryanarayan S